An accomplished, results-driven professional with over twenty years of experience in the area of controlled release and microencapsulation. Recognized as a teacher and scholar with extensive knowledge in formulation, polymers, and surface active chemistries. Proven ability to partner with research organizations from multinational corporations to virtual companies. Exceptional communicator with demonstrated success building relationships across a broad spectrum of organizational leaders. Consistant track record in the development of commercial products.
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| • formulation science, controlled release, microencapsulation, drug delivery, other delivery systems, unique process technology, spray drying, project management |
| • management of the innovation process |
| • ingredient interactions, chemical and physical stability |
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| Managing Director, Jacobs Controlled Release Consulting, LLC |
| Also, Vice-President, Research & Development, Particle Dynamics, Int. |
| Current contracts with contract research organizations, nutritional supplement company, several specialty pharma companies, cosmetic ingredients company, excipient suppliers, agricultural chemical company, and several law firms |
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Director, Drug Delivery Technology (4/2007 - 2/2009)
KV Pharmaceutical
St. Louis, Missouri, 63144 USA
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| • Development of commercial products include parenteral product for veterinary medecine sold worldwide (spray chilling), nutritional supplement sold in U.S., Europe, and Australia (spray dried) using patented bioavailability enhancement technology, controlled release generic pharmaceutical using unique fluid bed and other process technology (completed BE studies and being scaled up), two spray dried pharmaceutical products for bioavailability enhancement advanced through clinicals, a spray dried cosmetic ingredient, controlled release products for dogs using buccal delivery techniques, and development and commercialization of widely used pharmaceutical excipient made by spray drying. |
| • Design of commercial spray drying equipment for solvent applications and micro-scale applications. |
| • Development of new taste masking technologies for human and animal use. |
| • One of the pioneers in the field of controlled release technology used in oilfield applications. |
| • Development of techniques used in the microencapsulation and controlled release of pesticides. Co-authored a book chapter on controlled release delivery strategies in pesticides. Developed techniques for extended release pesticides in including Bt products. |
| • Invited lecturer at numerous international symposia, including AAPS and CRS. |
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| B.S. Chemistry, Drexel University, Philadelphia, PA. |
Ph.D. The Johns Hopkins University, Baltimore, MD.
Major: Organic Chemistry
Minors: Molecular Biology, Biochemistry
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| Research Associate: College of Pharmacy, The Ohio State University |
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Director, R & D, Particle and Coating Technologies, Inc.
(2002 - 2007) |
Director, Chemical Technology, Particle and Coating Technologies
(1994 - 2002) |
Research Associate, (Research Faculty) Microencapsulation and Granulation Laboratory, Chemical Engineering Dept., Washington University, St. Louis, MO
(1989 - 1994) |
Specialist, Petrolite Corporation, research and development in oil well stimulation applications, surfactant and formulation chemistries, controlled release applications
( 1981 - 1989) |
Training Supervisor for a division of Ingersoll Rand Corporation, conducted technical training programs and management development courses. Project manager on design and installation of gas processing equipment.
(1979 - 1981) |
Assistant Professor of Chemistry, Rockhurst College, Kansas City, MO Courses taught in Organic Chemistry, Organic Chemistry Laboratory, General Chemistry, Biochemistry and Laboratory, Pharmacology, and Environmental Science
(1975 - 1979) |
Lecturer and Course Director for the Center for Professional Advancement, course in Microencapsulation and Particle Coating and course in Drug Delivery Fundamentals
(1999 - 2007) |
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| "Spray-dried vaccine preparation comprising aluminum adsorbed immunogens", U.S. Patent 5,902,565, May 1999 |
| "Trends in Spray Drying of High Value Food Ingredients", keynote address at Food Science and Industry Board Australia Conference, March 2000 |
| "Microencapsulation", with R. E. Sparks and N.S. Mason, chapter in the book Pharmaceutical Unit Operations - Coating, Interpharm Press, 1999 |
| "Polymer Delivery Systems Concepts", with N.S. Mason, Polymeric Delivery Systems, ACS Symposium Series No. 520, 1993 |
| "Introduction to Microencapsulation Methods" with R. E. Sparks, chapter in the book, Controlled-Release Pesticides, H. Scher, editor, Marcel Dekker, 1999 |
| "Centrifugal Suspension-Separation", with R.E. Sparks, and N.S. Mason, Polymeric Delivery Systems, ACS Symposium Series No. 520, 1993 |
| "Bleaching Agent", U.S. Patent 5,336,433, August 9, 1994 |
| "Compositions and Methods of Adjusting Steroid Hormone Metabolism Through Phytochemicals", with M.A. Zeligs, U.S. Patent #6086915, July 2000 |
| "Formulations and Use of Controlled-Release Indole Alkaloids", with M.A. Zeligs, U.S. Patent 6,416,793, July 9, 2002 |
| "Method of Producing Porous Tablets with Improved Dissolution Properties", with R.E. Sparks and N.S. Mason, U.S. Patent 6,544,552, April 8, 2003 |
| "Development of formulation and equipment for spray drying of high value active ingredients for the pharmaceutical industry", presented at Particles 2006, Orlando Florida |
| "The Confused Senior", presented at workshop at 2008 Meeting of the Controlled Release Society, Los Angelos, Copenhagen Denmark, 2008 |
| "Use of Lipids in Controlled Release Formulations - A Brief Review", meeting of the American Association of Pharmaceutical Scientists, Los Angelos, CA 2009 |
| "Amorphous solid dispersions", with W. Rocco et al, U.S. Patent 7,713,548, May 11, 2010 |
| "Coated Pellets", Iris Ziegler, Irwin Jacobs, U.S. Patent Application 20100068290, (Assignee Grunenthal, GmbH) |
Several invited lectures at meetings of the AAPS and the Controlled Release Society within the last five years included weekend workshops at the 2008 CRS meeting on Oral Delivery Formulation for Challenging Patient Groups, the 2009 CRS Meeting Microencapsulation Workshop on spray drying and an invited presentation at the 2009 AAPS National Meeting on Controlled Release Lipid Formulations. Other presentations include posters and papers given at meetings of the American Chemical Society and meetings and workshops of the Controlled Release Society and American Association of Pharmaceutical Scientists. An invited lecture series on fluid bed coating was given in Singapore and the keynote address at a spray drying conference in Melbourne, Australia. Other recent invited lectures included the topics of scale-up studies, taste-masking, nanotechnology as applied to bioavailability enhancement.
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| Editorial advisory board for "Pharmaceutical Formulation and Quality" |
| Course director, Center for Professional Advancement: Courses in Microencapsulation and Particle Coating, Drug Delivery |
| Consulting work for several pharmaceutical and chemical manufacturers |
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